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Article History

Received: 1 November 2017

Revised: 17 January 2018

Accepted: 19 January 2018

First Online: 10 February 2018

Compliance with ethical standards

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (name the institution/committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: For this type of study, formal consent is not required.

: Doron S Comaneshter and Shlomo Vinker certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript. Joel Hanhart has given lectures for Novartis.