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Article History

Received: 9 July 2020

Revised: 29 September 2020

Accepted: 4 December 2020

First Online: 29 January 2021

Compliance with ethical standards

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: Mingwu Wang holds US, Canadian, Korean and Australian patents for topical application of ambroxol for treatment of ocular surface diseases. The other authors have no commercial or proprietary interest in any concept or products described in this article.

: The protocol was approved by the University of Arizona (Tucson, AZ, USA) and Shenzhen Eye Hospital Institutional Animal Care and Use Committees (Shenzhen, Guangdong, China). The study was conducted in compliance with the Tenets of the Declaration of Helsinki and the Association for Research in Vision and Ophthalmology statement for the use of animals in ophthalmic and visual research.

: Not applicable.

: All authors consent to the submission of the manuscript for publication.

: The content is solely the responsibility of the authors and does not necessarily represent the official views of the government funding agencies or other funders.