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Article History

Received: 23 September 2021

Revised: 20 January 2022

Accepted: 3 February 2022

First Online: 3 March 2022

Declarations

:

: The HARBOR trial was conducted in accordance with Good Clinical Practice (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use [ICH] E6), applicable US Food and Drug Administration regulations, the Health Insurance Portability and Accountability Act, and the tenets of the Declaration of Helsinki. The trial protocol was approved by institutional review boards and ethics committees as applicable.

: Written informed consent was obtained from all participants in the HARBOR trial.

: Not applicable.

: KBF has served as a consultant to Allergan, Bayer HealthCare, Carl Zeiss Meditec, Genentech, Inc., Heidelberg Engineering, Novartis, and Regeneron, and has received grant support from Genentech, Inc. and Roche. GS has served as a consultant to Allergan, Apellis, Bayer HealthCare, Boehringer Ingelheim, CenterVue, Chengdu Kanghong, Genentech, Inc., Heidelberg Engineering, Novartis, and Roche; received grant support from Carl Zeiss Meditec, CenterVue, Heidelberg Engineering, Nidek, Optos, Optovue, Quantel Medical, and Topcon; received lecture fees from Bayer HealthCare, Heidelberg Engineering, Nidek, Novartis, and Roche; and declares patents and/or royalties from Ocular Instruments. JJJ has served as a consultant to Carl Zeiss Meditec. SZ has served as a consultant to Allergan, Bayer HealthCare, Novartis, and Roche, and received grant support from Bayer HealthCare and Novartis. MC has received grant support from Bayer HealthCare, CenterVue, and Nidek. LH has served as a consultant to Aerpio, Alimera, Genentech, Inc., PolyPhotonix, and RecensMedical. SB and SG are employees of Genentech, Inc. MT was an employee of Genentech, Inc. during the course of this study (current employee of Kodiak Sciences Inc.).