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Article History

Received: 19 August 2025

Revised: 30 September 2025

Accepted: 14 October 2025

First Online: 17 November 2025

Change Date: 26 November 2025

Change Type: Update

Change Details: After the paper has been published online, the corresponding author noticed that the images of Figures 1, 5 and 6 are blurry and requested it to be replaced. The figures have now been replaced with the new one.

Declarations

:

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Ethics committee of the Institutional Doctors Association Westfalen Lippe, Münster, Germany (file number 2017–033-f-S) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.

: Anna Vahldiek, Lukas Heine, Benja Vahldiek, Jasper Schröter, Jan-Niklas Wolf, Michael Swora, Lars Reissberg, and J. Kleesiek report no financial disclosures.Laurenz Pauleikhoff reports consultancy with Bayer. Daniel Pauleikhoff reports consultancy with Bayer, Novartis, Heidelberg Engineering, and Roche.