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Authors
Rizza, A. N.
Benchek, Penelope
Khan, Rehana
Liu, Renee
Chan, E. Ricky
Li, Ashley
Susarla, Gayatri
Han, Sam
Huynh, Katie
Cheng, Ching-Yu
Li, Hengtong
Wong, Tien Yin
Craig, Jaime E.
McComish, Bennet J.
Gurung, Rajya L.
Burdon, Kathryn
Raman, Rajiv
Mathavan, Sinnakaruppan
Sobrin, Lucia
Iyengar, Sudha K. https://orcid.org/0000-0001-7488-250X
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Brustoski, Kim
Yang, Janine
Lains, Ines
Khetan, Vikas
Sripriya, Sarangapani
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Funding
Funding for this research was provided by:
Foundation for the National Institutes of Health (R01 EY027134)
Rajiv Gandhi Centre for Biotechnology, Department of Biotechnology, Ministry of Science and Technology, India (BT/PR22701/MED/15/166/2016)
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Article History
Received: 21 May 2025
Revised: 2 October 2025
Accepted: 11 November 2025
First Online: 27 February 2026
Declarations
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: This study was approved by the institutional review boards of the Vision Research Foundation, Case Western Reserve University, and Mass General Brigham. All participants provided informed consent, and the research adhered to the tenets of the Declaration of Helsinki.
: Informed consent was obtained from all individual participants included in the study.
: Patients signed informed consent regarding publishing their data and photographs.
: Financial Interests: A. N. Rizza receives financial support from the Department of Biotechnology, Government of India to fund this current manuscript.Penelope Benchek owns stock in Crispr Therapeutics.Ines Lains receives financial support from the NIH/NEI (grant number K12 EY016335) and has patents for US11049227B2 and US20210116461A1.Ching-Yu Cheng receives consulting fees for Medi-Whale.Tien Yin Wong receives consulting fees for Abbvie Pte Ltd Personal, Aldropika Therapeutics, Bayer, Boehringer-Ingelheim, Carl Zeiss, Genentech, Novartis, Opthea Limited, Plano, Quaerite, Biopharm Research Ltd, Regeneron Pharmaceuticals Inc, Roche, Sanofi, and Shanghai Henlius. He is the inventor, and hold patents for start‐up companies EyRiS and Visre, which have interests in, and develop digital solutions for eye diseases, including diabetic retinopathy.Bennet J. McComish receives grant support from the Royal Hobart Hospital Research Foundation.Kathryn Burdon receives grant support from the National Health and Medical Research Council Australia.Sarangapani Sripriya receives financial support from the Department of Biotechnology, Government of India to fund this current manuscript.Sinnakaruppan Mathavan receives financial support from the Department of Biotechnology, Government of India to fund this current manuscript.Lucia Sobrin receives grant support from the National Eye Institute (R01 EY027134) to fund this present manuscript.Sudha K. Iyengar receives grant support from the Veterans Association Grant (1I01BX003364-01A1) National Eye Institute (R01EY027134) to fund this present manuscript. Non-Financial Interests: The authors have no relevant non-financial interests to disclose.
