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Article History

Received: 1 April 2022

Revised: 9 October 2022

Accepted: 25 October 2022

First Online: 11 November 2022

Declarations

:

: The samples were collected with informed consent and under approved local ethical protocols from each patient.

: CV received speaker fees from AstraZeneca and Roche. SMB received advisory board honoraria and/or speaker fees from AstraZeneca, Roche, Novartis, GSK, MSD, Targos, Molecular Health, Merck, QuIP GmbH, and advisory board honoraria, speaker fees, and non-financial support from Janssen and BMS. JF received a speakers fee from Bristol Myers Squibb. SWR received speaker fees from Invitae and AstraZeneca. AH has received honoraria for lectures or consulting/advisory boards for Abbvie, AstraZeneca, BioNTech, BMS, Boehringer Ingelheim, Cepheid, Diaceutics, Illumina, Ipsen, Janssen, Lilly, MSD, NanoString, Novartis, Qiagen, QUIP GmbH, Roche, 3DHistotech. RE has received honoraria from Roche, Eisai, Pfizer, and Novartis and travel grants from BioNTech. The institution of A.H. and R.E. conducts research for AstraZeneca, Roche (CRO: palleos healthcare GmbH), Janssen-Cilag, Zytomed Systems, NanoString Technologies, Veracyte, Biocartis, Novartis, Cepheid, and BioNTech. WW has attended Advisory Boards and served as speaker for Roche, MSD, BMS, AstraZeneca, Pfizer, Merck, Lilly, Boehringer, Novartis, Takeda, Bayer, Amgen, Astellas, Eisai, Johnson&Johnson, Janssen, Illumina, Siemens, Agilent, ADC, GSK, and Molecular Health. WW receives research funding from Roche, MSD, BMS, and AstraZeneca. NP Speaker Fee and Traveling support: AstraZeneca, Illumina, Thermo Fisher Scientific, Roche, Novartis & BMS; Advisory Boards: Bayer, Lilly, Novartis, Roche. AJ received honoraria as well as travel and accommodation reimbursement for participants in advisory boards of Amgen, AstraZeneca, Biocartis, QuIP GmbH, and Novartis for activities as a speaker for Amgen, AstraZeneca, Bayer Pharmaceuticals, Biocartis, BMS, Boehringer Ingelheim, Merck KgA, Lilly, MSD, Novartis, Qiagen, Roche Pharma, Takeda, and Thermo Fisher. IH, AL, MB, LD, RS, LB, WD, MD, DH, and MH: none declared.