de Andrade Rufino, Rodrigo
Mota-Ortiz, Sandra Regina
De Lima, Miguel Antonio Xavier
Baldo, Marcus Vinicius C.
Canteras, Newton Sabino
Funding for this research was provided by:
Fundação de Amparo à Pesquisa do Estado de São Paulo (#2014/05432-9, #2009/53390-5, #2014/02540-5, #2016/10389-0)
Article History
Received: 19 July 2018
Accepted: 25 February 2019
First Online: 7 March 2019
Compliance with ethical standards
:
: There is no conflict of interest.
: Experiments were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publications No. 80-23, 1996). All experimental procedures had been previously approved by the Committee on The Care and Use of Laboratory Animals of the Institute of Biomedical Sciences, University of São Paulo, Brazil (Protocol number 085/2012). In the present study, the experiments were planned to minimize the number of animals used and their suffering. In addition, all surgical procedures were performed under deep anesthesia, and analgesic and antibiotic medications were given postoperatively.