Fernandes, Juan Matheus Pereira
Sena, Edlainne Pinheiro Ferreira
Schwarz, Marcos Gustavo Araujo
Corrêa, Meydson Benjamim Carvalho
Hardoim, Daiana de Jesus
Carneiro, Katia
d’ Escoffier, Luiz Ney
Souza, Celesta da Silva Freitas de
Zaverucha do Valle, Tânia
da Silva Calabrese, Kátia
Funding for this research was provided by:
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/210.618/2024)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (309493/2025-0)
Article History
Received: 5 December 2025
Accepted: 7 May 2026
First Online: 20 May 2026
Declarations
:
: The authors declare no competing interests.
: Experiments in mice were authorized by FIOCRUZ Ethics Committee (CEUA FIOCRUZ L0001/07) and IOC Ethics Committee (CEUA-IOC L014/2019). Access to Leishmania amazonensis was registered on SISGen under number AAE018A, and genetically modified organisms were handled under license CQB nº 313/10.
: TZV revised data analysis, wrote the main manuscript text, and provided part of the financial support; KS reviewed the manuscript and supervised the project; KC performed and analysed gel filtration and the first series of blotting; LNE did MALTI TOF/TOF experiment and analysis, CSFS did mice experiments, DJH performed FACs experiments and analysis, MGAS and MBCC performed blotting experiments and clones sequencing; EPFS did the biology molecular experiments including cloning, expression and protein isolation; JMPF did mice and cytokine experiments and put together data for the manuscript.