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Authors
Foco, Luisa https://orcid.org/0000-0002-6694-3322
De Bortoli, Marzia https://orcid.org/0000-0002-1348-1304
Del Greco M, Fabiola https://orcid.org/0009-0007-0023-6901
Frommelt, Laura S.
Volani, Chiara https://orcid.org/0000-0003-3600-4735
Riekschnitz, Diana A.
Motta, Benedetta M. https://orcid.org/0000-0002-6681-2170
Fuchsberger, Christian https://orcid.org/0000-0002-5918-8947
Delerue, Thomas https://orcid.org/0000-0002-6725-5361
Völker, Uwe https://orcid.org/0000-0002-5689-3448
Huan, Tianxiao https://orcid.org/0000-0001-5840-9413
Gögele, Martin
Winkelmann, Juliane https://orcid.org/0000-0002-3074-599X
Dörr, Marcus https://orcid.org/0000-0001-7471-475X
Levy, Daniel https://orcid.org/0000-0003-1843-8724
Waldenberger, Melanie https://orcid.org/0000-0003-0583-5093
Teumer, Alexander https://orcid.org/0000-0002-8309-094X
Pramstaller, Peter P. https://orcid.org/0000-0002-9831-8302
Rossini, Alessandra https://orcid.org/0000-0002-0440-1130
Pattaro, Cristian https://orcid.org/0000-0002-4119-0109
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Funding
Funding for this research was provided by:
Joint Project Alto Adige-SNSF (10.003.119)
Autonomous Province of Bolzano/Bozen - South Tyrol - Department of Innovation, Research, University and Museums
European Regional Development Fund (FESR1157)
Ministry of Health of the Autonomous Province of Bolzano and the South Tyrolean Sparkasse Foundation
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Article History
Received: 28 April 2025
Accepted: 5 July 2025
First Online: 30 July 2025
Declarations
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: CP has received consultant fees from Quotient Therapeutics. All other authors declared no conflicts of interest.
: CHRIS study was approved by the Ethics Committee of the Healthcare System of the Autonomous Province of Bolzano/Bozen, South Tyrol (approval number 21-2011). MICROS study was approved by the Provincial Ethics Committee of Bolzano/Bozen - South Tyrol (23.5 Dr.MVH/31.05.07.14/19644) with an update approved by the Ethics Committee of the Healthcare System of the Autonomous Province of Bolzano/Bozen - South Tyrol (18/09/2013). The research involving human stem cell lines was approved by the Ethics Committee of the Province of Bolzano (approval number 1/2014). SHIP-START and SHIP-TREND were approved by the Ethics Committee at the University Medicine Greifswald (approval number BB 39/08). The studies conform to the Declaration of Helsinki, and with national and institutional legal and ethical requirements. All participants included in the analysis gave oral and written informed consent.
