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Article History

Received: 24 July 2020

Accepted: 11 November 2020

First Online: 16 November 2020

Compliance with ethical standards

:

: Y. Miura reports receiving personal fees from ONO Pharmaceutical, Bristol Myers Squibb, MSD, and Chugai separate to the submitted work. M. Ando reports receiving personal fees from Asahi Kasei Pharma Corp. and grants from Kyowa Kirin Co. Ltd. separate to the submitted work. K. Yamazaki reports receiving personal fees from Chugai Pharma, Daiichi Sankyo, Yakult Honsha, Takeda, Bayer, Merck Serono, Taiho Pharmaceutical, Lilly, Sanofi, Ono Pharmaceutical, MSD, and Bristol-Myers Squibb separate to the submitted work. S. Hironaka reports receiving grants and personal fees from Chugai Pharma and Yakult Honsha during the conduct of the study; grants and personal fees from Sanofi, Ono Pharma, Taiho Pharma and AstraZeneca; and personal fees from Bristol-Myers Squibb Japan, Daiichi Sankyo, Lilly, Merck, Tsumura & Co., Nihonkayaku, and MSD. K.K., Shionogi, Astellas Pharma, Takeda, Boehinger Ingelheim, Kyowa Hakko Kirin, Pfizer, and Toyama Chemical Co. separate to the submitted work. N. Boku reports receiving research grants from Ono, Taiho, and Takeda and honorarium from Ono, Bristol-Myers Squibb, and Taiho separate to the submitted work. K. Muro reports receiving grants and personal fees from Ono and Sanofi; grants from Daiichi Sankyo, Parexel International, Shionogi Pharma, Sumitomo Dainippon, MSD, Pfizer, Mediscience Planning, and Solasia Pharma; and personal fees from Eli Lilly, Chugai, Takeda, Taiho, Bristol-Myers Squibb, and Bayer separate to the submitted work. I. Hyodo reports receiving grants and personal fees from Chugai Pharmaceutical Co. Ltd., Daiichi Sankyo Co. Ltd., Bristol-Myers Squibb Co., Taiho Pharmaceutical Co. Ltd., and Ono Pharmaceutical Co. Ltd.; personal fees from Eli Lilly Japan and Asahi Kasei Pharma Corp.; and grants from Takeda Pharmaceutical Co. Ltd. separate to the submitted work.

: The WJOG4407G trial protocol was approved by the ethics committees of all participating centers.

: Written informed consent was obtained from all enrolled patients in the WJOG4407G trial.