Ninomiya, Kiichiro
Yokoyama, Toshihide
Hotta, Katsuyuki
Oze, Isao
Katsui, Kuniaki
Hata, Tae
Yoshioka, Hiroshige
Bessho, Akihiro
Hosokawa, Shinobu
Kuyama, Shoichi
Kudo, Kenichiro
Kozuki, Toshiyuki
Harada, Daijiro
Yasugi, Masayuki
Murakami, Toshi
Nakanishi, Masamoto
Takigawa, Nagio
Maeda, Yoshinobu
Kiura, Katsuyuki
,
Article History
Received: 13 July 2020
Accepted: 18 February 2021
First Online: 1 March 2021
Declarations
:
: The study protocol was approved by the Ethics Review Board at each participating trial site and conducted according to the Helsinki Declaration, and registered at Clinical Trials Registry (UMIN000013133). See the Materials and Methods section.
: All patients signed written informed consent prior to the initiation of any study interventions. See the Materials and Methods section.
: The publication for this study was described in the protocol in advance, and appropriate consent had been obtained from all patients.
: The authors whose names are listed immediately below report the following details of affiliation or involvement in an organization or entity with a financial or non-financial interest in the subject matter or materials discussed in this manuscript.KN has received honoraria outside the current work from AstraZeneca, MSD, BMS, Boehringer-Ingelheim, Chugai Pharmaceutical, Eli Lilly, Taiho Pharmaceutical and Ono Pharmaceutical. TY has received honoraria outside the current work from Chugai Pharmaceutical, Boehringer-Ingelheim, Taiho Pharmaceutical, MSD, AstraZeneca and Ono Pharmaceutical. KH has received honoraria outside the current work from Pfizer, Eli Lilly, AstraZeneca, BMS, Ono Pharmaceutical, MSD, Chugai Pharmaceutical, Nippon Kayaku, Taiho Pharmaceutical, Boehringer-Ingelheim, Novartis, Daiichi-Sankyo, and Kyorin. KH also has received research funding outside of the current work from Eli Lilly, AstraZeneca, BMS, MSD, Chugai Pharmaceutical, and Astellas. KK has received honoraria outside the current work from Daiichi-Sankyo, Eisai, Chugai Pharmaceutical, Bayer, MSD, Oncolys BioPharma, and AstraZeneca. KK belongs to the endowed course funded by Tsuyama Chuo Hospital. AB has received honoraria outside the current work from Boehringer Ingelheim, AstraZeneca, Pfizer, Chugai, Ono Pharmaceutical, BMS, Novartis, Kyorin, Daiichi Sankyo, and FUJIFILM Toyama. AB also has received research funding outside the current work from AstraZeneca, Pfizer, Ono Pharmaceutical, Kyorin, AbbVie and FUJIFILM Toyama. TK has received outside the current work from Chugai Pharmaceutical, AstraZeneca, Eli Lilly, Taiho Pharmaceutical, BMS, Ono Pharmaceutical, MSD, Pfizer, Kyowa Kirin, Boehringer Ingelheim, Nippon Kayaku, and Novartis. TK also has received research funding outside the current work from Chugai Pharmaceutical, AstraZeneca, Eli Lilly, Taiho Pharmaceutical, BMS, and Merck Biopharma. DH has received outside the current work from Ono Pharmaceutical, BMS, Kyowa Kirin, AstraZeneca, Boehringer Ingelheim, Eli Lilly, MSD, Taiho Pharmaceutical, and Chugai Pharmaceutical. DH also has received research funding outside the current work from BMS, AstraZeneca, Eli Lilly, MSD, Chugai Pharmaceutical, Novartis, Kissei Pharmaceutical, Takeda Pharmaceutical, and Pfizer. NT has received outside the current work from AstraZeneca, Daiichi-Sankyo, Chugai Pharmaceutical, Taiho Pharmaceutical, Pfizer, Boehringer Ingelheim, Ono Pharmaceutical, MSD, Eli Lilly, Eisai, and BMS. NT also has received research funding outside the current work from AstraZeneca, Daiichi-Sankyo, Chugai Pharmaceutical, Taiho Pharmaceutical, Pfizer, Boehringer Ingelheim, Ono Pharmaceutical, MSD, Eli Lilly, Kyowa Kirin, and Nippon Kayaku. YM has received honoraria outside the current work from Pfizer, Mundipharma, Kyowa Kirin, BMS, Chugai Pharmaceutical, and Celgene. YM also has received research funding outside the current work from Kyowa Kirin, BMS, Chugai Pharmaceutical, Eisai, and Nippon Shinyaku. KK has received research funding outside the current work from Ono Pharmaceutical, Boehringer Ingelheim, Taiho Pharmaceutical, Chugai Phamaceutical, and BMS. All the other authors declare no conflicts of interest regarding this study.