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Intraoral vs. extraoral photobiomodulation therapy for oral mucositis in head and neck cancer patients: a multicenter, randomized, single-blind clinical trial

Crossref DOI link: https://doi.org/10.1007/s00520-025-09877-w

Published Online: 2025-09-10

Published Print: 2025-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Klein, Isadora Peres

Pinto, Mariana Bitu Ramos

Só, Bruna Barcelos

de Farias Gabriel, Amanda

Mendonça, Nathália Felix

da Cruz Santos, Letícia Beatriz

Farias, Karina Morais

Mores, Ana Leticia

Martins, Marco Antonio Trevizani

Silva, Ana Carolina Prado Ribeiro e

Brandão, Thaís Bianca

Santos-Silva, Alan Roger

Alves, Fábio Abreu

Martins, Manoela Domingues
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Article History

Received: 11 February 2025

Accepted: 18 August 2025

First Online: 10 September 2025

Declarations

:

: The study was approved by the Ethics Committee of the Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil (no. 2020-0189); A.C.Camargo Cancer Center, São Paulo, Brazil (no. 3033/21); and the Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil, in accordance with Good Clinical Practice guidelines and Brazilian law. The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants.

: Manoela D. Martins would like to disclose that she serves on Azena Medical as a consultant.

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