Yang, Aoran
Pan, Chen
Gu, Chengli
Luo, Baihe
Gao, Feng
Hou, Yang
Shi, Yu
Funding for this research was provided by:
the National Natural Science Foundation of China (No. 82471971)
Liaoning Province Science and Technology Joint Plan (2023JH2/101700127)
the Leading Young Talent Program of Xingliao Yingcai in Liaoning Province (XLYC2203037)
Liaoning Provincial Science and Technology Program (2025-BS-0581)
Article History
Received: 14 August 2025
Accepted: 14 January 2026
First Online: 3 February 2026
Declarations
:
: The authors declare no competing interests.
: This study is a prospective single-center clinical trial, which has been registered in the U.S. Clinical Trials Database ( ) with the trial registration number NCT06526442. The registration date was October 9th, 2020. This study was complied with the Health Insurance Portability and Accountability Act and was approved by the Institutional Review Board (IRB) of Shengjing Hospital of China Medical University (Human Research Ethics Committee approval 2022PS1006K and 2022PS1006K(T2)), with written informed consent obtained from all participants. Patients were recruited between Jan 2022 and Oct 2025. For mice, all of the protocols were followed the guidelines of the Institutional Animal Care and Use Committee (IACUC), and were approved by the Medical Ethics Committee of our local hospital (approval number 2023PS1082K).