Ishihara, Yo
Ihara, Eikichi
Esaki, Mitsuru
Takahashi, Kota
Tomita, Naoki
Dang, Thanh Huy
Ohira, Mayumi
Horiuchi, Mayu
Uchida, Ayaka
Toriumi, Yukiko
Nishizawa, Toshihiro
Ohkubo, Hidenori
Imajo, Kento
Oyamada, Shunsuke
Iwasaki, Tomoyuki
Kurihashi, Takeo
Yamauchi, Atsushi
Nakazato, Michiko
Nakajima, Atsushi
Kessoku, Takaomi https://orcid.org/0000-0002-5587-1386
Clinical trials referenced in this document:
Documents that mention this clinical trial
Dependence-related screening positivity among regular stimulant-laxative users with chronic constipation: a multicenter prospective observational study
https://doi.org/10.1007/s00535-026-02455-9
Funding for this research was provided by:
International University of Health and Welfare
Article History
Received: 22 April 2026
Accepted: 24 May 2026
First Online: 29 May 2026
Declarations
:
: A. Nakajima receives grants and research support from Gilead, Mylan EPD, EA Pharma, Kowa, Taisho, and Biofermin, and is a consulting adviser for Gilead, Boehringer Ingelheim, BMS, Kowa, Astellas, EA Pharma, and Mylan EPD. E. Ihara receives lecture honoraria from Takeda Pharmaceutical Co., Ltd., EA Pharma Co., Ltd., Viatris Inc., and Mochida Pharmaceutical Co., Ltd. Y. Ishihara receives a research grant from Shionogi & Co., Ltd.
: This study was approved by the Ethics Committee of the International University of Health and Welfare Narita Hospital (June 27, 2023; Approval No. 23-Nr-009). Additional approvals were obtained from the Ethics Committee of Kanagawa Dental University Yokohama Clinic (Approval No. 957; September 9, 2023) and Iwasaki Internal Medicine Clinic (Approval No. 23-1; August 1, 2023).
: Written informed consent was obtained from all participants prior to enrollment.