Jamaludin, A. http://orcid.org/0000-0002-0096-5625
Kadir, T. http://orcid.org/0000-0002-4414-2401
Zisserman, A. http://orcid.org/0000-0002-8945-8573
McCall, I.
Williams, F. M. K. http://orcid.org/0000-0002-2998-2744
Lang, H.
Buchanan, E. http://orcid.org/0000-0001-5378-808X
Urban, J. P. G. http://orcid.org/0000-0002-5780-6713
Fairbank, J. C. T. http://orcid.org/0000-0002-0050-874X
Funding for this research was provided by:
Engineering and Physical Sciences Research Council (EP/M013774/1)
FP7 Science in Society (HEALTH-F2-2008-201626)
FP7 Ideas: European Research Council (FP7/2007–2013)
Back to Back Charity (1079089)
Article History
Received: 15 October 2022
Revised: 10 February 2023
Accepted: 12 February 2023
First Online: 30 March 2023
Declarations
:
: The author declare that they have no conflict of interest.
: OSCLMRIC Data are available upon reasonable request—deidentified participant data are available via corresponding author. Other data sets are available via the websites quoted.
: At what stage in the research process were patients/the public first involved in the research and how? Automated annotation has been presented through BackCare patients’ charity and in a public question and answer session at the Back Pain Show, Birmingham May 2017 and subsequent interactive podcasts. The symptomatic group and asymptomatic cohort have had PPI input in their clinical and research settings. The Oxford Spine Clinic is a serial recruiting setting for clinical studies with regular interactions with large numbers of patients concerning back pain research (EB). How were the research question(s) and outcome measures developed and informed by their priorities, experience, and preferences? MRI is considered essential by many patients and current guidance discourages the use of imaging for the investigation of back pain (EB). How were patients/the public involved in the design of this study? Not directly, but epidemiology issues were raised in public discussions. How were they involved in the recruitment to and conduct of the study? These subjects were recruited anonymously based on reporting back pain and having suitable imaging. TwinsUK has a full explanation of its history and recruitment on its website: ExternalRef removed. It is stated in the Methods that subjects were not involved in the design of this study.
: TwinsUK: (ExternalRef removed). Genodisc: (ExternalRef removed). OSCLMRIC: (HRA approved, IRAS Project ID 207858). The University of Oxford is the sponsor of this research, in keeping with the requirements of the UK Policy Framework for Health and Social Care Research 2017. Health Research Authority approval for receipt and analysis of anonymised retrospective patient data was received in 2016 (project reference 207858). August 25th 2016 Title Oxford Secondary Care Lumbar MRI Cohorts (OSCLMRIC) to assist in the development of an image analysis methodology to analyse clinical MRI studies in subjects with low back pain syndromes and asymptomatic controls. PID 12139 Protocol Number 12139. Date/version 23/08/2016; v9.0; Minor amendments (to increase scope of recruitment and duration) were requested 18th March 2019). All the subjects in this report had been recruited before this date. IRAS Project ID: 207858 REC Reference: 16/HRA/4532 Short Study Title: Oxford Secondary Care Lumbar MRI Cohorts (OSCLMRIC) Date complete amendment submission received: 18th March 2019 Sponsor Amendment Reference Number: NSA 1—change of secondary objective, increase in sample size, extension of study duration, etc. Sponsor Amendment Date: 18 March 2019. Amendment Type: Non-Substantial Outcome of HRA and HCRW. Assessment: HRA and HCRW Approval for the amendment 22nd June 2022. TwinsUK is covered by serial ethics approvals available through its website ExternalRef removed.