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Article History

Received: 23 March 2022

Accepted: 26 June 2022

First Online: 24 July 2022

Declarations

:

: The authors declare no conflicts of interest for this article.

: This study was approved by the Research Ethics Committee of Kyorin University Faculty of Medicine. Informed consent was obtained from the patients enrolled in this study when available. For the remaining patients for whom consent was not available due to unavoidable circumstances, such as patient death, the abovementioned ethics committee provided permission to use their tissue in the experiments. This was a retrospective study using existing specimens. Based on the Declaration of Helsinki and the ethical guidelines established by the government (ethical guidelines for medical research targeting humans), the information on the research was made public, and opt-out consent was obtained from patients to guarantee the opportunity for refusal.