Kobayashi, Daiki https://orcid.org/0009-0007-0072-1042
Hiono, Takahiro https://orcid.org/0000-0001-8897-3592
Adachi, Ryota
Igarashi, Manabu
Matsushita, Takahiko
Isoda, Norikazu
Sakoda, Yoshihiro
Matsuoka, Koji
Funding for this research was provided by:
Japan Society for the Promotion of Science (23KJ0059)
Japan Society for the Promotion of Science (24K09260)
Japan Society for the Promotion of Science (22KK0094)
Japan Science and Technology Agency (JPMJSP2119)
Ministry of Education, Culture, Sports, Science and Technology (1801)
Takahashi Industrial and Economic Research Foundation
Takeda Science Foundation
Japan Agency for Medical Research and Development (JP253fa627005)
Japan International Cooperation Agency (JP23jm0110019)
Article History
Received: 29 September 2025
Accepted: 17 January 2026
First Online: 26 February 2026
Declarations
:
: All experiments involving genetically modified organisms were authorized by the Safety Committee on Genetic Recombination Experiments of Hokkaido University (approval no. 2021-026). This study was approved by the Biosafety Management Committee on Pathogens and Other Hazardous Agents of the Faculty of Veterinary Medicine, Hokkaido University (approval nos. 2024-1-68 and 2024-1-71).
: The authors declare no conflicts of interest regarding the content of this study.