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Article History

Received: 19 April 2018

Accepted: 28 June 2018

First Online: 13 July 2018

Conflict of interest

: PdPL declares no conflicts of interest. JAL declares no conflicts of interest. EMH (as President of The Institute of Cellular Metabolism) declares as follows: The Institute of Cellular Metabolism (IMC) is a private non-profit organization whose sole purpose, according to its statutes, is Scientific Research in Biochemistry and Molecular Biology. IMC research is supported primarily from its own resources although it may eventually receive grants from other institutions. The IMC has been founded as anindependentScientific Research Institution in order to avoid dependency on governmental policies, which at times are not based on good scientific criteria. The Institute of Cellular Metabolism runs a nutritional clinic in which patients are advised on adequate nutrition, based on the results of our research, under medical supervision when necessary, offering the recommended products, such as amino acids and vitamins, under current European and USA legislations. The entirety income obtained from this activity, which in this case can involve a patent (applied for, but not yet admitted), to use glycine in osteoarthritis treatment, is dedicated to supporting our scientific research. The IMC has also destined a large part of its resources to subsidize grants and fellowships for researchers from other institutions, and in no case has it entailed any personal financial profit for IMC members or other persons.

: This work did not involve experiments with human participants or laboratory experiments with animals since all cartilage samples were made with steers materials obtained from a local abattoir whose protocols were in accordance with the current legislation under sanitary supervision.