Kleist, Christine J. http://orcid.org/0000-0002-5045-4938
Choe, Chi-Un
Atzler, Dorothee http://orcid.org/0000-0002-6551-1544
Schönhoff, Mirjam
Böger, Rainer http://orcid.org/0000-0003-3770-5357
Schwedhelm, Edzard http://orcid.org/0000-0003-3597-6276
Wicha, Sebastian G. http://orcid.org/0000-0002-8773-4845
Funding for this research was provided by:
Universität Hamburg
Article History
Received: 22 December 2021
Accepted: 1 May 2022
First Online: 26 May 2022
Declarations
:
: The authors have no competing interests to declare that are relevant to the content of this article.
: For the in silico pharmacometric approach, data from a previous clinical study were used. The clinical study was approved by the Ethics Committee of the Hamburg Board of Physicians (PV4038), conducted in accordance with the Declaration of Helsinki and registered at clinicaltrials.gov (NCT02675660).
: Data were obtained from a previous clinical study, we received the data without access to personal information of the study participants. No individual can be identified by the data.