Nozoe, Akira
Ohata, Yasuhisa
Fujiwara, Makoto
Yamamoto, Kenichi
Nambara, Toshihiko
Nakano, Chiho
Miyagawa, Kazuaki
Kogo, Mikihiko
Taketani, Takeshi
Kubota, Takuo
Kitabatake, Yasuji
Tanaka, Susumu
Ozono, Keiichi https://orcid.org/0000-0002-6517-8825
Funding for this research was provided by:
Japan Society for the Promotion of Science London (JP21H02881)
Japan Society for the Promotion of Science London (JP23K07225)
Japan Society for the Promotion of Science London (JP22FC0201)
Japan Society for the Promotion of Science London (JP22K17181)
The University of Osaka
Article History
Received: 4 April 2025
Accepted: 30 January 2026
First Online: 14 March 2026
Declarations
:
: T.K. received a research grant from Alexion Pharma, Kyowa Kirin, and Teijin Pharma; consulting fees from Kyowa Kirin and Alexion Pharma, and payments from Kyowa Kirin, Teijin Pharma, and Alexion Pharma. K O. received payments from Kyowa Kirin, Alexion Pharma, and Novo Nordisk Pharma. The other authors declare no conflicts of interest.
: The present study, including the experimental procedures for skin biopsy and iPSC production, was approved by the Osaka University Graduate School of Medicine and Shimane University Medical Hospital ethical committee [approval numbers: 13123 (823)-4 and 1110].
: Written informed consent was obtained from the parents or legal guardians of the patients in accordance with the Declaration of Helsinki.