Article History
Received: 17 January 2020
Revised: 22 January 2020
Accepted: 27 January 2020
First Online: 3 February 2020
Compliance with ethical standards
: Ethics approval was from the University of Western Ontario ethics board and all patients signed informed consent to be enrolled in the registry.
: A.F.C. received salary support from the Scleroderma Society of Ontario and St. Joseph’s Hospital Foundation, London, Ontario (Kay Eldson donor). A.F.C. received consulting fees from Actelion. M.K. has no conflicts of interest. J.E.P. received consulting fees from Actelion, Bayer, BMS, Pfizer, and Roche. Some of the topical tadalafil was received as samples from Delivra, Inc.