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Article History

Received: 27 February 2020

Accepted: 16 October 2020

First Online: 17 November 2020

Compliance with ethical standards

:

: RC has received lecture fees and/or travel grants from Biogen, Celgene, Genzyme, Novartis, and Sanofi. VBM has received funding for travel, speaker honoraria, and research support from Bayer Schering, Biogen, Merck Serono, and Sanofi Genzyme. MM has received consulting fees, speaker honoraria, and travel grants from Almirall, Bayer, Biogen, Merck, Novartis, Sanofi Genzyme, and Teva. CG has received funding for invited speaker or travel expenses for attending meetings from Biogen, Genzyme, Merck Serono, Novartis, Sanofi, and Teva. CS has received speaker honoraria from Biogen and Teva, honoraria for serving on advisory boards from Merck and Sanofi, and travel grants from Biogen, Merck, Novartis, Roche, and Teva. RT has received funding for travel or speaker honoraria from Alfa Wasserman, Bayer, Biogen, CLS Bering, Merck Serono, Novartis, Roche, Sanofi, and Teva. NDR has received speaker honoraria from Biogen, Genzyme, Novartis, and Sanofi, funding for participation in advisory boards from Novartis and Sanofi Genzyme, and support for travel to scientific meetings from Almirall, Biogen, Novartis, Roche, Sanofi Genzyme, and Teva. SM and VZ are employees of and may hold stock and/or stock options in Biogen. FP has received personal compensation for speaking and serving on advisory boards from Almirall, Bayer, Biogen, Celgene, Merck, Novartis, Roche, Sanofi, and Teva.

: All patients signed an informed consent before enrollment, and the study protocol was approved by local ethics committees.