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Authors
Can Demirdöğen, Birsen https://orcid.org/0000-0002-1536-6123
Kılıç, Osman Oğuzhan https://orcid.org/0000-0003-4779-8390
Karagülle, Elif Naz https://orcid.org/0000-0002-6207-7543
Kalmaz, Latife Mekselina https://orcid.org/0000-0003-0746-3502
Mungan, Semra https://orcid.org/0000-0002-6469-5185
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Article History
Received: 10 October 2021
Accepted: 27 December 2021
First Online: 29 January 2022
Declarations
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: This study protocol was approved by the Ethical Committee of Ankara City Hospital.
: All subjects gave written informed consent.
: The authors declare no competing interests.
: This study reveals the first evidence of the involvement of single nucleotide polymorphisms around the connective tissue growth factor (<i>CTGF</i>) gene in relapsing–remitting multiple sclerosis (RRMS) risk and disability progression. The downstream variant rs9399005 was associated with RRMS and a higher rate of disability progression reflected by a higher Multiple Sclerosis Severity Score (MSSS). Furthermore, MSSS was significantly lower in patients with at least one rs12526196C allele than in the corresponding patients with the wild-type genotype. These data indicate a role for the variants in the region flanking <i>CTGF</i> gene in RRMS risk and disability progression.
