Takashima, Atsuo
Shitara, Kohei
Fujitani, Kazumasa
Koeda, Keisuke
Hara, Hiroki
Nakayama, Norisuke
Hironaka, Shuichi
Nishikawa, Kazuhiro
Kimura, Yutaka
Amagai, Kenji
Fujii, Hirofumi
Muro, Kei
Esaki, Taito
Choda, Yasuhiro
Takano, Toshimi
Chin, Keisho
Sato, Atsushi
Goto, Masahiro
Fukushima, Norimasa
Hara, Takuo
Machida, Nozomu
Ohta, Manabu
Boku, Narikazu
Shimura, Masashi
Morita, Satoshi
Koizumi, Wasaburo
Funding for this research was provided by:
Taiho Pharmaceutical
Article History
Received: 22 January 2018
Accepted: 17 May 2018
First Online: 31 May 2018
Compliance with ethical standards
:
: KS reports personal fees from Astellas, Bristol-Myers Squibb, Takeda, Pfizer, Novartis, Abbvie and Yakult, grants and personal fees from Lilly and Ono Pharma, grants from Sumitomo Dainippon Pharma, MSD, Daiichi-Sankyo, Taiho Pharma and Chugai Pharma outside the submitted work. HH reports grants from AstraZeneca, Daiichi-Sankyo, Sumitomo Dainippon Pharma, Lilly, Merck Serono, MSD, Ono Pharma, Taiho Pharma, Chugai Pharma, Boehringer Ingelheim, Eisai, LSK BioPharma, Incyte and Pfizer outside the submitted work. SH reports personal fees from Lilly and Taiho Pharma outside the submitted work. KN reports grants and non-financial support from Taiho Pharma during the conduct of the study, and personal fees from Taiho Pharma, Chugai Pharma, Yakult, Lilly, Ajinomoto Pharma outside the submitted work. KA reports other from Taiho Pharma during the conduct of the study, and other from MSD outside the submitted work. KM reports grants from Ono Pharma, MSD, Daiichi-Sankyo, Kyowa Hakko Kirin, Shionogi Pharma and Gilead Sciences, and personal fees from Chugai Pharma, Taiho Pharma, Takeda, Merck Serono, Lilly and Yakult outside the submitted work. TE reports grants and personal fees from Lilly, Taiho Pharma, Merck Serono and Ono Pharma, grants from Novartis, Daiichi-Sankyo, Sumitomo Dainippon Pharma, AstraZeneca, Boehringer Ingelheim and MSD, and personal fees from Chugai Pharma, Nippon Kayaku and Eisai outside the submitted work. TT reports grants and personal fees from Taiho Pharma during the conduct of the study, and personal fees from Daiichi-Sankyo, Kyowa Hakko Kirin and Eisai, grants and personal fees from Chugai Pharma and Novartis, and grants from Takeda, Ono Pharma, MSD and Merck Serono outside the submitted work. AS reports personal fees from Taiho Pharma outside the submitted work. MG reports grants, personal fees and non-financial support from Taiho Pharma during the conduct of the study, grants, personal fees and non-financial support from Ono Pharma, Yakult, Chugai Pharma, Kyowa Hakko Kirin and Mochida Pharma, personal fees and non-financial support from Takeda, Novartis, and Bayer outside the submitted work. NM reports grants from Taiho Pharma during the conduct of the study, and grants from Ono, MSD and Lilly outside the submitted work. NB reports grants from Taiho Pharma during the conduct of the study, and grants and personal fees from Taiho Pharma and Bristol-Myers Squibb outside the submitted work. MS reports personal fees from Taiho Pharma outside the submitted work. SM reports personal fees from Taiho Pharma during the conduct of the study, and personal fees from Bristol-Myers Squibb outside the submitted work. WK reports grants, personal fees and non-financial support from Taiho Pharma during the conduct of the study. All remaining authors have no conflicts of interest to declare.
: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.
: All patients provided written informed consent.