Text and Data Mining valid from 2019-02-20
Received: 6 December 2018
Accepted: 18 January 2019
First Online: 20 February 2019
Compliance with ethical standards
: M. Kono has received grants from Pfizer Japan Inc. M. Fukata has received grants from Shino-Test Corporation; personal fees from Pfizer, Daiichi Sankyo Company, Bayer Yakuhin, and Boehringer Ingelheim. T. Esaki has received grants and personal fees from Eli Lilly, Taiho, Daiichi-Sankyo, Merck Serono, and Ono; grants from Novartis, DS pharma, MSD and Boehringer; personal fees from Chugai, Bristol, Eisai and Takeda. K. Akashi has received grants and personal fees from Mitsubishi Tanabe Pharma Corporation, Daiichi-Sankyo, MSD, Eisai, Astellas Pharma, Sanofi, Chugai Pharmaceutical, Asahi Kasei Pharma, Kyowa Hakko Kirin, Sumitomo Dainippon Pharma, Bristol-Myers Squibb, Takeda Pharmaceutical, Novartis Pharma, Alexion Pharmaceuticals, Teijin Pharma, Nippon Shinyaku, Yakult Honsha, Mundipharma and Bayer Yakuhin; grants from Ono Pharmaceutical, Merck Serono, Toyama Chemical, Taiho Pharmaceutical, Otsuka Pharmaceutical, Yakult Honsha Co, AbbVie, Shionogi, Eli Lilly Japan, Taisho Toyama Pharmaceutical, Mochida Pharmaceutical, The Chemo-Sero-Therapeutic Research Institute., Merck Serono, Nippon Kayaku, Japan Blood Products Organization, and Shin Nippon Biomedical Laboratories; personal fees from Celgene, Janssen Pharmaceutical, Pfizer, Medical Review, Amgen Astellas Biopharma and Shire Japan. E. Baba has received grants, personal fees and non-financial support from Eli Lilly Japan; grants and personal fees from Daiichi-Sankyo, Bristol-Myers Squibb, Taiho Pharmaceutical. Eisai, Yakult Honsha, and Ono Pharmaceutical; grants from Bayer Yakuhin, MSD, Linical; personal fees from Takeda Pharmaceutical, Sumitomo Dainippon Pharma, Kyowa Hakko Kirin, Sanofi, Merck Serono, Tsumura, Chugai Pharmaceutical, and Astellas Pharma. All of the remaining authors declare that they have no conflicts of interest.
: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.
: Informed consent or substitute for it was obtained from all patients for being included in the study.