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Article History

Received: 29 April 2020

Accepted: 7 June 2020

First Online: 22 June 2020

Compliance with ethical standards

:

: Dr. Fujitani reports personal fees from Taiho Pharmaceutical Co., Eli Lilly, Bristol-Myers Squibb, Ono Pharmaceutical Co. and Yakult Honsha Co. Ltd. outside the submitted work. Dr. Nakamura reports grants from Ministry of Health, Labour and Welfare, Japan, Japan Agency for Medical Research and Development (AMED) during the conduct of the study, and personal fees from Taiho Pharmaceutical Co., Chugai Pharmaceutical Co. and Bayer outside the submitted work. Mr. Mizusawa reports grants from Ministry of Health, Labour and Welfare, Japan, Japan Agency for Medical Research and Development (AMED) during the conduct of the study, and personal fees from Taiho Pharmaceutical Co. outside the submitted work. Dr. Kuwata reports grants from Ono Pharmaceutical Co. and Daiichi-Sankyo Pharmaceutical Co., and personal fees from AstraZeneca and MSD outside the submitted work. Dr. Katayama reports grants from Ministry of Health, Labour and Welfare, Japan, Japan Agency for Medical Research and Development (AMED) during the conduct of the study, and personal fees from Johnson & Johnson outside the submitted work. Dr. Yoshikawa reports personal fees from Ono Pharmaceutical Co., Bristol-Myers Squibb, MSD, Taiho Pharmaceutical Co., Chugai Pharmaceutical Co., Pfizer, Nihon Kayaku Pharmaceutical Co., Covidien, Johnson and Johnson, Olympus and Eli Lilly outside the submitted work. Dr. Boku reports grants from Taiho Pharmaceutical Co. and Ono Pharmaceutical Co., and personal fees from Taiho Pharmaceutical Co, Ono Pharmaceutical Co. and Bristol-Myers Squibb outside the submitted work. Dr. Terashima reports personal fees from Taiho Pharmaceutical Co., Chugai Pharmaceutical Co., Ono Pharmaceutical Co., Bristol-Myers Squibb, Yakult Honsha Co. Ltd., Takeda Pharmaceutical Co., Eli Lilly, Pfizer and Daiichi Sankyo Pharmaceutical Co. outside the submitted work. Dr. Fukuda reports grants from National Cancer Center and the Ministry of Health, Labour and Welfare of Japan during the conduct of the study, and personal fees from Taiho Pharmaceutical Co. and Chugai Pharmaceutical Co. outside the submitted work. Dr. Sano reports personal fees from Taiho Pharmaceutical Co., Chugai Pharmaceutical Co., Eli Lilly, Daiichi Sankyo Pharmaceutical Co. and Ono Pharmaceutical Co. outside the submitted work. Dr. Sasako reports personal fees from Taiho Pharmaceutical Co. during the conduct of the study, and personal fees from Chugai Pharmaceutical Co., Yakult Honsha Co. Ltd., Ono Pharmaceutical Co., Eli Lilly, Bristol-Myers Squibb and Sanofi Aventis outside the submitted work. The remaining authors declare that they have no conflict of interest.

: All study procedures were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

: Informed consent to be included in the study, or the equivalent, was obtained from all patients.

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