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Article History

Received: 27 May 2020

Accepted: 28 June 2020

First Online: 13 August 2020

Compliance with ethical standards

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: Dr. Terashima reports personal fees from Taiho, Chugai, Ono, BMS, Yakult, Takeda, Eli Lilly, Pfizer, and Daiichi Sankyo outside the submitted work. Dr. Fujitani reports personal fees from Taiho Pharmaceutical Co., Eli Lilly, Bristol-Myers Squibb, Ono Pharmaceutical Co., and Yakult Honsha Co. Ltd. outside the submitted work. Dr. Ando reports grants from Kyowa Kirin, Co. Ltd. outside the submitted work. Dr. Kodera reports grants from Taiho Pharma, Chugai Pharma, Takeda, MSD, NIhon Kayaku, Yakult, Lilly Japan, Ono Pharma, Kaken Pharma, Covidien, EA Pharma, Novartis, KCI, Maruho, Daiichi Sankyo, Otsuka, Tsumura, Sawai, Bristol, and Sanofi, as well as personal fees from Taiho Pharma, Chugai Pharma, Lilly Japan, Johnson & Johnson, Takeda, Yakult, Otsuka, Ono Pharma, Covidien, and MSD outside the submitted work. Dr. Yoshida reports grants and personal fees from Taiho Pharm, Asahi Kasei Pharma, Chugai Pharm., Covidien Japan, Daiichi Sankyo, Eisai, Eli Lilly Japan, Johnson & Johnson, MerkSerono, MSD, Nippon Kayaku, Novartis, Ono Pharm., Otsuka Pharm., Sanofi, Takeda Pharm., Tsumura, Yakult Honsha; grants from Abbott, Abbvie, Astellas, Biogen Japan, Celgene, GlaxoSmithKline, KCI, Koninklijke Philips, Kyowa Kirin, Meiji Seika Pharma, Toray Medical; and personal fees from AstraZeneka, Bristol-Myers Squibb, Denka, EA Pharma, Olympus, Pfizer, Sanwa Kagaku Kenkyusho, SBI Pharma, Teijin Pharma, and TERUMO outside the submitted work. Dr. Yoshikawa reports personal fees from MSD, ONO, BMS, TAIHO, Chuigai, Pfizer, Lilly, Johnson & Johnson, Terumo, and Daiichi-Sankyo outside the submitted work. Dr. Shimada reports grants from ONO PHARMACEUTICAL CO., LTD., TAIHO Pharmaceutical Co., Ltd., CHUGAI PHARMACEUTICAL CO., LTD., Eli Lilly Japan K.K, Yakult Honsha Co., Ltd., Nippon Kayaku Co., Ltd., Medical & Biological Laboratories Co., Ltd., and Alfresa Corporation, as well as personal fees from Oncolys BioPharma Inc. outside the submitted work. Dr. Sakamaki, Dr. Ito, Dr. Ninomiya, Dr. Kondo, Dr. Oka, Dr. Kawada, Dr. Morita, Dr. Imamura, Dr. kaji, Dr. Takagane, Dr. Kawabata, and Dr. Tanizawa have nothing to declare.

: All procedures were conducted in accordance with the ethical standards of the corresponding committees on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions (revised in 213). Informed consent was obtained from all patients prior to study participation.

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