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Article History

Received: 2 July 2021

Accepted: 13 September 2021

First Online: 22 September 2021

Declarations

:

: M. Ando received Grants from Kyowa Kirin Co. Ltd., outside of the submitted work. Tanizawa received personal fees from Johnson & Johnson, Japan Covidien Corporation, and Daiichi Sankyo, outside of the submitted work. Yamada received personal fees from ONO, BMS, Johnson & Johnson, Taiho, and Nippon Kayaku, outside of the submitted work. Fukushima received Grants from Ono Pharmaceutical Co., Ltd., and Grants from Taiho Pharmaceutical Co., Ltd., and Chugai Pharmaceutical Co., Ltd, outside of the submitted work. Choda received personal fees from ONO PHARMA, Bristol-Myers Squibb, and Eli Lilly Japan, outside of the submitted work. Kodera received Grants and personal fees from Taiho Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., Yakult Honsha Co., Eli Lilly Japan K.K., Pharmaceutical Co., Ltd., Kaken Pharmaceutical Co., Ltd., Covidien Japan Co., Ltd., and Otsuka Pharmaceutical Co., Ltd.; Grants from Daiichi Sankyo Co., Ltd., MSD K.K., EA Pharma Co., Novartis Pharma K.K., KCI K.K., Maruho Co., Ltd., TSUMURA & Co., Sawai Pharmaceutical Co., Bristol-Myers Squibb, and Sanofi K.K.; and personal fees from Johnson & Johnson K.K. and MSD K.K., outside of the submitted work. Yoshida received Grants and personal fees from Asahi Kasei Pharma, Chugai Pharma, Covidien Japan, Daiichi Sankyo, Eli Lilly Japan, Johnson & Johnson, MerkSerono, MSD, Nippon Kayaku, Novartis Pharma, Ono Pharm., Otsuka Pharm., Sanofi, Taiho Pharm., Takeda Pharm., TERUMO, Tsumura & Co., Yakult Honsha; Grants from Abbott, Abbvie, Astellas, Biogen Japan, Celgene, Eisai, EP‐CRSU, EPS Corporation, FUJIFILM, GlaxoSmithKline K.K., Kaken Pharm., Kyowa Kirin, Meiji Seika Pharma, Philips, and Toray Medical; and personal fees from AstraZeneca, Bristol-Myers Squibb Japan, Denka Co., Ltd., EA Pharma, Olympus, Pfizer, Sanwa Kagaku Kenkyusho, SBI Pharma, and Teijin Pharma, outside of the submitted work. All remaining authors declare that they have no conflict of interest.

: All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent should for the study, or an equivalent, was obtained from all patients.

: This article does not contain any studies using animal subjects performed by any of the authors.

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