Lin, Daniel https://orcid.org/0000-0003-1352-8915
Quan, Wenying
Garretson, Marne
Chirikov, Viktor
Chen, Clara
Singh, Prianka
Davis, Catherine
Sugarman, Ryan
Clinical trials referenced in this document:
Documents that mention this clinical trial
Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies
https://doi.org/10.1136/jitc-2019-000404
Nivolumab (NIVO) + chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): 4 year (yr) follow-up of CheckMate 649.
https://doi.org/10.1200/jco.2024.42.3_suppl.306
Updated quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis of nivolumab plus chemotherapy versus chemotherapy alone as first-line (1L) treatment for advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma (GC/GEJC/EAC): 4-year (yr) follow-up from CheckMate 649 (CM 649).
https://doi.org/10.1200/jco.2024.42.16_suppl.4044
Q-TWiST analysis of first-line nivolumab plus chemotherapy versus chemotherapy in patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma from CheckMate 649: 4-year follow-up results
https://doi.org/10.1007/s10120-025-01634-6
First-line (1L) nivolumab (NIVO) plus chemotherapy (chemo) vs chemo in patients (pts) with advanced gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 Chinese subgroup analysis 4-year (yr) follow-up.
https://doi.org/10.1200/jco.2024.42.3_suppl.318
Real-world (RW) effectiveness of nivolumab plus chemotherapy (NIVO+chemo) in patients (pts) with advanced or metastatic gastric carcinoma, gastroesophageal junction carcinoma, or esophageal adenocarcinoma (GC/GEJC/EAC).
https://doi.org/10.1200/jco.2024.42.3_suppl.295
Nivolumab (NIVO) + chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): 4-year follow-up of CheckMate 649.
https://doi.org/10.1200/jco.2024.42.16_suppl.4040
Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): 3-year follow-up from CheckMate 649.
https://doi.org/10.1200/jco.2023.41.16_suppl.4025
Health-Related Quality of Life With Nivolumab Plus Chemotherapy Versus Chemotherapy in Patients With Advanced Gastric/Gastroesophageal Junction Cancer or Esophageal Adenocarcinoma From CheckMate 649
https://doi.org/10.1200/jco.23.00170
Current status and future potential of predictive biomarkers for immune checkpoint inhibitors in gastric cancer
https://doi.org/10.1136/esmoopen-2020-000791
First-line (1L) nivolumab (NIVO) plus chemotherapy (chemo) vs chemo in patients (pts) with advanced gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 Chinese subgroup analysis with 3-year follow-up.
https://doi.org/10.1200/jco.2023.41.4_suppl.353
Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): 3-year follow-up from CheckMate 649.
https://doi.org/10.1200/jco.2023.41.4_suppl.291
Health-related quality of life (HRQOL) in patients (pts) with advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC) or esophageal adenocarcinoma (EAC): 36-month results of nivolumab plus chemotherapy (N+C) versus (C) from CheckMate 649.
https://doi.org/10.1200/jco.2023.41.16_suppl.4038
First-Line Nivolumab Plus Chemotherapy for Advanced Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma: 3-Year Follow-Up of the Phase III CheckMate 649 Trial
https://doi.org/10.1200/jco.23.01601
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gastrointestinal cancer
https://doi.org/10.1136/jitc-2022-006658
Funding for this research was provided by:
Bristol-Myers Squibb
Article History
Received: 10 February 2025
Accepted: 10 June 2025
First Online: 9 July 2025
Declarations
:
: D. Lin reports consulting or advisory role at AstraZeneca, Agenus, and Exelixis; stock and other ownership interests in BioNano Genomics; and honoraria from AstraZeneca, Agenus, and Exelixis. V. Chirikov reports employment at OPEN Health; and research funding from AstraZeneca and Bristol Myers Squibb/Celgene. C. Chen reports employment at AstraZeneca; and stock and other ownership interests in Bristol Myers Squibb/Celgene. P. Singh reports employment at Bristol Myers Squibb. All other authors have no relationships to disclose.