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Authors
Naher, Sayeda Kamrun https://orcid.org/0000-0002-9540-2760
Espinoza, David
Grimison, Peter
Shitara, Kohei
Pavlakis, Nick
Goldstein, David
Stockler, Martin R.
Mercieca-Bebber, Rebecca
Sjoquist, Katrin Marie
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Funding
Funding for this research was provided by:
National Health and Medical Research Council (post graduate research scholarship)
National Health and Medical Research Council (NHMRC Early Career Fellowship (APP1138100).)
The University of Sydney
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Article History
Received: 13 June 2025
Accepted: 21 August 2025
First Online: 16 September 2025
Declarations
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: Nick Pavlakis: Honoraria—BeiGene, Bayer, Takeda, and Pierre Fabre; Consulting or Advisory Role—Roche, Boehringer Ingelheim, AstraZeneca, Merck KGaA, Merck Serono, Amgen, Merck Sharp & Dohme, Novartis, Pfizer, Takeda, Bristol Myers Squibb, BeiGene, Gilead Sciences, and Janssen Oncology; Research Funding—Bayer (Inst), Pfizer (Inst), and Roche (Inst). Kohei Shitara: Honoraria—Bristol Myers Squibb, Janssen, AstraZeneca, Lilly, Ono Pharmaceutical, and Astellas Pharma; Consulting or Advisory Role—Bristol Myers Squibb, Takeda, Ono Pharmaceutical, MSD, Novartis, Daiichi Sankyo, Amgen, Astellas Pharma, Guardant Health, Bayer, Zymeworks, AstraZeneca, and ALX Oncology; Research Funding—MSD (Inst), Daiichi Sankyo (Inst), Taiho Pharmaceutical (Inst), Chugai Pharma (Inst), Ono Pharmaceutical (Inst), Astellas Pharma (Inst), Eisai (Inst), Amgen (Inst), and PRA Health Sciences (Inst). Katrin Sjoquist: Honoraria—BMS, Merck, MSD, Servier, Novotech (Inst), Astellas Pharma, Lisata (Inst), and Bayer (Inst); Research Funding—Bayer (Inst); Other Relationship—Novotech. List of where and when the study has been presented: ASCO Gastrointestinal Cancers Symposium (GI) 2025—mini oral and poster presentation.
: The trials were approved by HRECs prior to initiation/patient recruitment. For INTEGRATE IIa—ClinicalTrials.gov identifier: NCT04879368. For INTEGRATE trial- clinical trial registration: ANZCTR 12612000239864.
: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients.
