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Authors
Zhang, Bo
Wang, Jiacai
Chen, Xiaoxue
Xue, Tao
Xin, Jie
Liu, Yanjuan
Wang, Xiao
Li, Xinpeng
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Funding
Funding for this research was provided by:
Shandong Provincial Natural Science Foundation (ZR2021LZY030, ZR2023MD070)
Key R&D Program of Shandong Province (2021CXGC010508)
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Article History
Received: 22 January 2024
Accepted: 24 August 2024
First Online: 29 August 2024
Declarations
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: The authors declare no competing interests.
: The animal study was reviewed and approved by Linyi University Animal Ethics Committee. The animal experiments complied with the ARRIVE guidelines. The male rats were relatively strong, while the female rats were relatively weak, and other factors (such as food and living environment) were unlikely to interfere with the experimental effect. One hundred and twenty male Sprague–Dawley rats were randomly divided into six groups after adapting to the environment, with 10 rats in each group. The parallel control group method was used. Rats were numbered first and then randomly divided into six groups. The experimental environment was maintained at a specific-pathogen-free level. The model of diabetes was established by injecting streptozotocin, and fucoidan was administered by gavage. After the experiment, rats were euthanized with CO<sub>2</sub>. Written informed consent was obtained from the owners prior to the participation of their animals in this study.
