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Authors
Li, Xiaobin
Yu, Wenjun
Yuan, Xiaolong
Li, Zhengke
Leng, Runlin
Gao, Xiang
Yang, Guohua
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Funding
Funding for this research was provided by:
Outstanding Young and Middle-aged Talents Training Program of Zhongnan Hospital of Wuhan University (ZNYQ2022002)
Innovation Incubation Fund of Zhongnan Hospital of Wuhan University (CXPY2023050)
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Article History
Received: 26 August 2025
Revised: 30 November 2025
Accepted: 22 December 2025
First Online: 15 January 2026
Declarations
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: This study was approved by the Life Science and Medical Ethics Committee of Wuhan University (Approval #WHU-LFMD-IRB2025008). All adult participants (aged ≥ 18 years) provided written informed consent for genetic research; for minors (aged < 18 years), written consent was obtained from their legal guardians. Blood samples were collected using a double-blind coding system (identity decoupled from sample identifiers), and data were stored on encrypted servers. No privacy breaches or ethical disputes occurred during the study.
: This study does not fall within the scope of a clinical trial; therefore, a clinical trial registration number is not applicable.
: The authors declare no competing interests.
