Kashihara, Naoki
Itano, Seiji https://orcid.org/0000-0002-9452-4117
Nakashima, Takaya
Goto, Tadahiro
Yoshihara, Keisuke
Eguchi, Shunsuke
Iekushi, Kazuma
Isaka, Yoshitaka
Nagasu, Hajime
,
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP25ek0109812)
Ministry of Health, Labour and Welfare (JPMH24FD1001)
Ministry of Health, Labour and Welfare (JPMH23FC1048)
Novartis Pharma K.K.
Article History
Received: 2 October 2025
Accepted: 10 November 2025
First Online: 18 November 2025
Declarations
:
: K.Y., S.E., and K.I. are employees of Novartis Pharma K.K. All other authors have declared no competing interests.
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the ethics committee of Kawasaki Medical School and Kawasaki Medical School Hospitals (IRB approval number 6899-00) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Because obtaining written or oral informed consent was difficult and the database provided fully anonymized information, the Clinical Research Act (Act No. 16, 2017) of the Ministry of Health, Labor and Welfare of Japan did not require investigators to obtain consent.