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Authors
Gunwhy, Ebony R. https://orcid.org/0000-0002-5608-9812
Hines, Catherine D. G.
Green, Claudia
Laitinen, Iina
Tadimalla, Sirisha
Hockings, Paul D.
Schütz, Gunnar
Kenna, J. Gerry
Sourbron, Steven
Waterton, John C.
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Funding
Funding for this research was provided by:
Innovative Medicines Initiative (116106)
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Article History
Received: 3 January 2024
Revised: 19 July 2024
Accepted: 23 July 2024
First Online: 6 August 2024
Declarations
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: ERG and ST declare no conflict of interest. CG (at the time of work), and GS are employees of Bayer AG, a for-profit company marketing the MR contrast agent gadoxetate, trade name Primovist (Eovist in the USA). IL was an employee of and received compensation from Sanofi-Aventis Deutschland GmbH at the time the work was performed and is currently an employee of Antaros Medical, a for-profit company engaged in the provision of imaging biomarker services. SS receives research support from Bayer AG for work unrelated to this study. PDH is an employee of Antaros Medical. JGK has received compensation from Bioxydyn Ltd. (a for-profit company engaged in the discovery and development of MR biomarkers and the provision of imaging biomarker services), provides fee for consultancy advice to various pharmaceutical companies, and undertakes paid consultancy of Cosmetics Europe, which is the European trade association for the cosmetics and personal care industry. JCW holds stock in Quantitative Imaging Ltd. and is a Director of, and has received compensation from, Bioxydyn Ltd. CDGH was an employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, and owned stock in Merck & Co., Inc., Rahway, NJ, USA at the time the work was performed and is currently an employee of GSK.
: All protocols in centre E were approved by the Institutional Animal Care and Use Committee, Merck, Sharp & Dohme LLC, and were in compliance with the 8th edition Guide for the Care and Use of Laboratory Animals published by the National Research Council (National Academies Press, revised 2011). The animal experiments at centre G were approved by Regierungspräsidium Darmstadt Veterinärdezernat (State of Hessen, Germany) and conducted at the AAALACi accredited animal facility. All animal studies at centre D were approved by local authorities in Berlin, Germany, and were conducted in compliance to German national and EU animal welfare regulations.
