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Article History

Received: 19 October 2017

Accepted: 28 January 2018

First Online: 20 February 2018

Compliance with ethical standards

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: Authors declare that our work conforms to the guidelines set forth in the Helsinki Declaration of 1975, as revised in 2000, concerning Human and Animal Rights, and that they followed the policy concerning Informed Consent.

: Naoki Sakakibara, Fumio Nagashima, and Takahiro Higashi have no conflicts of interest. Yasuo Hamamoto has conflicts of interest to declare with regard to this manuscript: Ono Pharmaceutical Co. Yuko Kitagawa has conflicts of interest to declare with regard to this manuscript: Ethicon, Ono Pharmaceutical Co., Taiho Pharma, Chugai Pharmaceutical co., Asahi Kasei Pharma, Otsuka Pharmaceutical Co., Kyowa Hakko Kirin Co., Daiichi Sankyo co., Takeda Pharmaceutical Co. Nippon Boehringer Ingelheim Co., Novartis Pharma., Pfeizer Japan, Merck Serono Co., Yakult Honsha co., Terumo Corporation, Torii Pharmaceutical Co., Astra Zeneca.