Document is current

Article History

Received: 15 July 2025

Accepted: 2 November 2025

First Online: 7 November 2025

Declarations

:

: SY has received honoraria for lectures from Ono Pharmaceutical, Bristol-Myers Squibb, MSD, and Taiho Pharmaceutical and Advisory Board for Ono Pharmaceutical and Bristol-Myers Squibb [outside of the submitted work]. YH has received research grants for Ono Pharmaceutical and Bristol Myers Squibb and honoraria for lectures from Ono Pharmaceutical and Bristol Myers Squibb, Novartis, MSD, Chugai phama, Eisai, Nutri, Bayer, Merck Biopharma, Eli Lilly, Teijin pharma, Taiho and Advisory Board for Jansen and Rakuten Medical Japan. [outside of the submitted work]. KK reports consulting fees from Bristol Myers Squibb and Merck Sharp and Dohme, BeiGene, Roche, AstraZeneca, and Bayer; honoraria from Ono Pharmaceuticals, Bristol Myers Squibb, and Taiho; research funding from Ono Pharmaceuticals, Bristol Myers Squibb, Merck Sharp and Dohme, BeiGene, Chugai, Shionogi, AstraZeneca, and Bayer for research subjects outside the submitted work. [outside of the submitted work]. The other authors declare that they have no conflicts of interest.

: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent or substitute for it was obtained from all patients for being included in the study.