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Role of POLE2/GINS1-mediated AKT/mTOR pathway in RCC autophagy, proliferation, and metastasis: evidences from bioinformatic, clinical, and experimental data

Crossref DOI link: https://doi.org/10.1007/s10495-025-02206-w

Published Online: 2026-03-27

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Su, Yajuan

Wang, Wentao

Wang, Xingyuan

Xu, Songlin

Li, Anrui

Teng, Lichen
Funding

Funding for this research was provided by:

Haiyan Founding project of Harbin Medical University Cancer Hospital (NO. JJMS 2022-14)

Innovation funding for technology of Harbin Medical University Cancer Hospital (NO. 2023-1-S-13)
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Text and Data Mining valid from 2026-03-27

Version of Record valid from 2026-03-27
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Article History

Received: 12 February 2025

Accepted: 23 November 2025

First Online: 27 March 2026

Declarations

:

: The authors declare no competing interests.

: For clinical samples, written informed consents were obtained, and the protocol was approved by the Ethical Committee of Harbin Medical University Cancer Hospital (No.KY2023-34). Animal experiments are conducted in accordance with ARRIVE guideline and approved by Experimental Animal Ethics Committee of Yangzhou University (No.202406026).

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