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Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress

Crossref DOI link: https://doi.org/10.1007/s10495-026-02262-w

Published Online: 2026-01-23

Published Print: 2026-02

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yang, Shizhou

Wu, Tingting

Cao, Zhu

Chen, Zhengyun

Ma, Yuejiang

Wang, Ting

Qian, Linhua

Huang, Xiufeng
Funding

Funding for this research was provided by:

Natural Science Foundation of Zhejiang Province (LQ20H160049)

Natural Science Foundation of Zhejiang Province (ZCLQN25H0401)

Natural Science Foundation of Zhejiang Province (LQ20H160054)

4+X Clinical Research Project of Women's Hospital, School of Medicine, Zhejiang University (ZDFY2021-4X202)
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Text and Data Mining valid from 2026-01-23

Version of Record valid from 2026-01-23
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Article History

Received: 12 September 2025

Accepted: 3 January 2026

First Online: 23 January 2026

Declarations

:

: The authors declare no competing interests.

: The animal experiments in this study were conducted following the ARRIVE guidelines and the “Guiding Principles in the Care and Use of Animals” (China) and approved by the Laboratory Animal Welfare & Ethics Committee of Women’s Hospital, School of Medicine, Zhejiang University (Approval Number: AE 20250014). The clinical samples of EC tumors and normal endometrial tissue were collected from patients with informed consent and ethical guidelines approved by the Ethics Committee of Women’s Hospital, School of Medicine, Zhejiang University (Approval number: IRB-20250185-R).

: Not applicable.

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