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Improvement of tacrolimus production in Streptomyces tsukubaensis by mutagenesis and optimization of fermentation medium using Plackett–Burman design combined with response surface methodology

Crossref DOI link: https://doi.org/10.1007/s10529-021-03144-8

Published Online: 2021-05-22

Published Print: 2021-09

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yan, Lingbin https://orcid.org/0000-0002-3713-3873
Zhang, Zhulan

Zhang, Yin

Yang, Huangjian

Qiu, Guanrong

Wang, Desen

Lian, Yunyang
Funding

Funding for this research was provided by:

Special Project of Public Welfare Research Institute of Fujian Province of China (2019R1005-8, 2020R1005009)
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Text and Data Mining valid from 2021-05-22

Version of Record valid from 2021-05-22
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Article History

Received: 7 June 2020

Accepted: 30 April 2021

First Online: 22 May 2021

Declarations

:

: The authors declare that they have no competing interests.

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