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Article History

Received: 21 December 2018

Accepted: 26 December 2018

First Online: 10 January 2019

Compliance with ethical standards

:

: HSR’s institution received research funding from Plexxikon, Macrogenics, OBI Pharma, Eisai, Pfizer, Novartis, Eli Lilly, Roche, and Merck. RSF received consulting fees from Pfizer, Bayer, Novartis, Bristol-Myers Squibb, Merck, Eli Lilly, Eisai, and Roche/Genentech as well as other research funding from Pfizer. VD received consulting fees from Genentech, Eli Lilly, Pfizer, Astellas, AbbVie, Novartis Pharma KK, Daichy, Tesaro, NSD, Seattle Genetics, and Roche-Peru, as well as speakers bureau fees from Pfizer, Novartis Pharma KK, and Roche-Peru. JE received consulting fees from Eli Lilly, Novartis, Pfizer, Roche, and Eisai, performed contracted research for Celgene, and received honoraria from Eli Lilly, Novartis, Pfizer, Roche, TEVA, and Pierre Fabre. AAJ received consulting fees from Amgen, AbbVie, AstraZeneca, BMS, Eli Lilly, Pfizer, Novartis, and Roche. NH received consulting fees for Eli Lilly, Novartis, and Pfizer. AC received consulting/advisory fees from Agendia. KAG received consulting/advisory fees from Pfizer, Novartis, AstraZeneca, NanoString Technologies, Merck, Eli Lilly, Genomic Health, Roche, Seattle Genetics, and Mylan. DJS received consulting fees from Pfizer, Eli Lilly, and Novartis, performed contracted research for Pfizer and Novartis, is a Pfizer stockholder, received travel accommodation/expenses from Pfizer and BioMarin, and has a leadership role with BioMarin. CHB, ERG, SI, DRL, and AM are employees of and own stock in Pfizer. OL has nothing to disclose.

: This trial complies with the current laws of the countries in which it was performed.