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Article History

Received: 14 January 2019

Accepted: 8 April 2019

First Online: 30 April 2019

Compliance with ethical standards

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: Ivana Sestak declares speaker’s fee from Myriad Genetics and Nanostring Technologies. Miguel Martin declares speaker’s honorarium from Pfizer and Lilly, is on the advisory board of AstraZeneca, Novartis, Roche-Genetech, Pfizer, Glaxo, Pharmamar, Taiho Oncology, Eli Lilly, and has received research grants from Novartis, Roche. Peter Dubsky declares grant support from Agendia, Sividon, Myriad Genetics, Nanostring, and advisory role for Amgen, and speaker’s fee from Myriad Genetics, Sividon, and Amgen. Ralf Kronenwett is an inventor on the Endopredict patent, employee and previous shareholder of Sividon. Federico Rojo is on advisory board for Roche, Merck, Pfizer, Genomic Health, Guadrant Health, Novartis, and Abbvie. Jack Cuzick has received research grants from AstraZeneca, Myriad Genetics, Memorial Sloan Kettering, Qiagen, Beckton Dickinson, Genera, Aventis Pharma, honoraria from Merck, Roche, Qiagen, Myriad Genetics, and is on the speaker’s bureau for Beckton Dickinson and Hologic. William Gradishar has received research grants from AstraZeneca, honoraria from Bayer, Boehringer Ingelheim, Eli Lilly, Merck, Novartis, Ratiopharm, and Roche. Hatem Soliman has received honoraria from Eli Lilly, AstaZeneca, Celgene, Novartis, and Pfizer. ARL has received research grants from Roche, Novartis, Pfizer, Merck and honoraria from Roche, Novartis, Pfizer, Merck, Pierre Fabre, and Eisai. Michael Gnant has received honoraria from Amgen, AstraZeneca, Celgene, EliLilly, Invectys, Pfizer, Nanostring, Novartis, Roche, is on the advisor board of AstraZeneca, EliLilly, and has received research grants from AstraZeneca, Novartis, Roche, Pfizer. Amparo Ruiz declares that he has no conflicts of interest. The other authors declared that they have no conflicts of interest.

: All procedures were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.