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Article History

Received: 23 April 2019

Accepted: 4 May 2019

First Online: 11 May 2019

Compliance with ethical standards

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: JS, ALB, RV, GR, JG, SCJ, ZZ, JH, AN, AMS, and KT declare that they have no conflict of interest. AB has received grants from Biothernostics Inc, Immunomedics, Novartis, Genentech/Roche, Merck, Radius Health, Spectrum Pharma, Innocrin, and Mersana Pharmaceuticals; consultant to Immunomedics, Novartis, Genentech/Roche, Merck, Radius Health, Spectrum Pharma, Taiho Pharma, Biothernostics Inc and Sanofi. GR has received grants from AxoGen and Allergan; patents US PCT/US2009/000,887, Europe 09710338.6-1222, Brazil PI0908087-2, licensed to Aegeria Soft Tissue; patent US 6 + 2/119,047 issued to Sonavex. DFH has received grants from Pfizer, Novartis and Astra Zeneca; Stock in Oncimmune LLC and Inbiomotion; Consultant/advisory panels with Cepheid, Freenome Inc, Artiman Ventures (CellWorks), CVS Caremark, Agendia Inc.; Sponsored Research with Merrimack Pharmaceuticals, Eli Lilly, Menarini Silicon BioSystems, Puma Biotechnology, Pfizer, Astra Zeneca; Patents US 8790, 878 B2 licensed to Menarini Silicon BioSystems. NLH has received grants from NIH, Pfizer, Novartis, AbbVie, H3 Biomedicine, and Innocrin Pharmaceuticals. VS has received grants from Abbvie, Biocept, Pfizer, Novartis, Medimmune, and Puma Biotechnology; data safety monitoring board for Immunomedics; consultant to Iridium Therapeutics, Inc.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.

: This article does not contain any studies with animals performed by any of the authors.