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Article History

Received: 9 October 2020

Accepted: 21 January 2021

First Online: 16 February 2021

Compliance with ethical standards

:

: AW reports a role as study investigator with Astellas during the conduct of this study, consulting/advisory roles with, and research funding from, AstraZeneca, Daiichi Sankyo, Lilly, MSD, Novartis, Pfizer, and Roche outside the submitted work, consulting/advisory roles with Athenex, Coleman Research, Gerson Lehrman, and Guidepoint outside the submitted work, director of Andrew Wardley Limited and the Manchester Cancer Academy, honoraria from AstraZeneca, Athenex, Daiichi Sankyo, Lilly, MSD, Novartis, Pfizer, and Roche, speaker’s bureau fees from AstraZeneca, Lilly, Novartis, Pfizer, and Roche, travel expenses from Daiichi Sankyo, MSD, and Roche, and research funding from Seattle Genetics. JC reports a role as study investigator with Astellas during the conduct of this study and consulting/advisory roles with AstraZeneca, Biothera, Celgene, Cellestia, Eisai, Novartis, Pfizer, and Roche outside the submitted work. LP reports a consulting/advisory role with, and research funding from, Astellas and Medivation during the conduct of this study, a consulting/advisory role with Lilly outside the submitted work, consulting/advisory roles and research funding from Novartis, Pfizer, and Roche outside the submitted work and research funding from GlaxoSmithKline, Merck, and Odonate outside the submitted work. KM, AJC, ICT, MH, RY, RB, LH, SC, PG, PN, and SR report a role as study investigator with Astellas during the conduct of this study. HSR received research funding from Astellas during the conduct of this study. J Steinberg and J Sugg are full-time employees of Astellas. VA reports a role as study investigator with Astellas during the conduct of this study, research funding from Genentech outside the submitted work, and consulting/advisory roles for AbbVie, Daiichi Sankyo, Eisai, and Novartis outside the submitted work. DC reports a role as study investigator with Astellas during the conduct of this study and consulting/advisory roles for Novartis, Pfizer, Roche, and Syntheon outside the submitted work. GSW reports a consulting/advisory role with, and research funding from, Astellas during the conduct of the study and research funding from AbbVie, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Lilly, G1 Therapeutics, Genentech, Incyte, Janssen, MacroGenics, Medivation, Merrimack, Novartis, Pfizer, and Tesaro outside the submitted work and stock holdings from Puma and Roche outside the submitted work. M-PG reports a role as study investigator with Astellas during the conduct of this study and consulting/advisory roles with Lilly, Novartis, Pfizer, and Roche outside the submitted work. IEK reports research funding from Pfizer during the conduct of the study, a consulting/advisory role with Astellas during the conduct of this study, a consulting/advisory role with, and research funding from, Genentech/Roche outside the submitted work, and consulting/advisory roles with Context, Daiichi Sankyo, MacroGenics, Novartis, and Taiho outside the submitted work.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.