Opdam, M.
van der Noort, V.
Kleijn, M.
Glas, A.
Mandjes, I.
Kleiterp, S.
Hilbers, F. S.
Kruger, D. T.
Bins, A. D.
de Jong, P. C.
Schiphorst, P. P. J. B. M.
van Dalen, T.
Flameling, B.
Rietbroek, R. C.
Beeker, A.
van den Heiligenberg, S. M.
Bakker, S. D.
Wymenga, A. N. M.
Oving, I. M.
Bijlsma, R. M.
van Diest, P. J.
Vermorken, J. B.
van Tinteren, H.
Linn, S. C. http://orcid.org/0000-0001-5541-0347
Funding for this research was provided by:
Stichting A Sister's Hope
Agendia
Article History
Received: 19 November 2021
Accepted: 30 April 2022
First Online: 19 May 2022
Declarations
:
: SCL reports grants from Agendia® and A Sister's Hope during the conduct of the study. SCL is an advisory board member for Cergentis, and IBM, and received institutional research support from AstraZeneca, Eurocept-pharmaceuticals, Genentech, Novartis, Pfizer, Roche, Tesaro, and Immunomedics. In addition, SCL received institutional non-financial support from AstraZeneca, Genentech, Novartis, Roche, Tesaro, and Immunomedics and institutional educational financial support from Bayer and Daiichi-Sankyo outside of this study. MK: Full/Part-time employment: Agendia. AG: Full/Part-time employment: Agendia. JBV reports an advisory/consultancy role for Innate Pharma, Merck Sharp & Dome Corp, PCI Biotech, Nanobiotix, WntResearch, and having received a Speaker Bureau/Expert testimony, lecture fee from Merck-Serono, and MSD. All other authors have declared no conflicts of interest.
: The IKA trial was approved by the central ethics committee of the Netherlands Cancer Institute. The trial was performed in accordance with the Declaration of Helsinki. For this retrospective translational study, no additional consent was required according to Dutch legislation, since the use of archival pathology left-over material does not interfere with patient care. This was also discussed with the Ethical, Legal, Social Implications (ELSI) service desk of the Netherlands. Tumor tissue was handled according to the Dutch code of conduct for responsible use of human tissue in the context of health research.
: All participating patients gave informed consent before randomization and agreed to be included in future survival analysis. For this retrospective translational study, no additional consent was required according to Dutch legislation.