Aldrich, Melissa B. http://orcid.org/0000-0002-8114-7607
Rasmussen, John C.
DeSnyder, Sarah M.
Woodward, Wendy A.
Chan, Wenyaw
Sevick-Muraca, Eva M.
Mittendorf, Elizabeth A.
Smith, Benjamin D.
Stauder, Michael C.
Strom, Eric A.
Perkins, George H.
Hoffman, Karen E.
Mitchell, Melissa P.
Barcenas, Carlos H.
Isales, Lynn E.
Shaitelman, Simona F.
Funding for this research was provided by:
NIH/NCI (5R01CA201487, P30CA016672)
Article History
Received: 23 March 2022
Accepted: 21 June 2022
First Online: 10 July 2022
Declarations
:
: EMS-M and JCR are listed as inventors on patents related to the near-infrared fluorescence lymphatic imaging used in this study, and may receive future financial benefit from its commercialization. EMS-M, JCR, and The University of Texas Health Science Center at Houston (UTHealth) have research-related financial interests in Lymphatic Science, Inc. SFS has grant funding from the Emerson Collective Foundation and research contract support from Artios Pharmaceuticals, Alpha Tau, and Exact Sciences. The remaining authors have no financial relationships or competing interests relevant to this article to disclose.
: The study was conducted in line with the principles of the 1964 Declaration of Helsinki and later amendments, with offlabel use of indocyanine green under FDA Investigational New Drug (IND) application 106,345. Approval was granted by the Institutional Review Boards/Committees for the Protection of Human Subjects at both UTHealth and MD Anderson Cancer Center. The study was conducted under the approval of the institutional review boards of both The University of Texas health Science Center at Houston and The University of Texas MD Anderson Cancer Center (under FDA combinational investigational new drug application 106,345 for off-label intradermal administration of indocyanine green (ICG) dye with NIRF-LI [NCT 02949726]).
: Written informed consent was obtained from all individual participants in the study, including consent for publication of de-identified images. Signed informed consent for participation and publication of results was obtained from all study subjects.