Rugo, Hope S. https://orcid.org/0000-0001-6710-4814
Campbell, Mike
Yau, Christina
Jo Chien, A.
Wallace, Anne M.
Isaacs, Claudine
Boughey, Judy C.
Han, Hyo S.
Buxton, Meredith
Clennell, Julia L.
Asare, Smita M.
Steeg, Katherine
Wilson, Amy
Singhrao, Ruby
Matthews, Jeffrey B.
Perlmutter, Jane
Fraser Symmans, W.
Hylton, Nola M.
DeMichele, Angela M.
Yee, Douglas
Van’t Veer, Laura J.
Berry, Donald A.
Esserman, Laura J.
Clinical trials referenced in this document:
Documents that mention this clinical trial
Impact of extent of disease at presentation on oncologic outcomes according to pathologic response to neoadjuvant systemic therapy among participants of the I-SPY2 clinical trial.
https://doi.org/10.1200/jco.2024.42.16_suppl.594
Is the NCI MATCH trial a match for gynecologic oncology?
https://doi.org/10.1016/j.ygyno.2015.11.003
Oral paclitaxel, carboplatin, and dostarlimab (OPE/Cb/D) without and with trastuzumab in early-stage, high-risk breast cancer: Results from the neoadjuvant I-SPY 2 TRIAL.
https://doi.org/10.1200/jco.2023.41.17_suppl.lba520
Improving prediction of response to neoadjuvant treatment in patients with breast cancer by combining liquid biopsies with multiparametric MRI: protocol of the LIMA study – a multicentre prospective observational cohort study
https://doi.org/10.1136/bmjopen-2022-061334
Correlation of HER2 low status in I-SPY2 with molecular subtype, response, and survival.
https://doi.org/10.1200/jco.2023.41.16_suppl.514
Association of germline polygenic risk for thyroid autoimmunity with overall survival in the I-SPY2 Trial.
https://doi.org/10.1200/jco.2024.42.16_suppl.10600
Therapeutic response and outcomes with less common breast cancer subtypes in the I-SPY trial 2011-2022.
https://doi.org/10.1200/jco.2024.42.16_suppl.582
Biomarkers predicting response to 5 immunotherapy arms in the neoadjuvant I-SPY2 trial for early-stage breast cancer (BC): Evaluation of immune subtyping in the response predictive subtypes (RPS).
https://doi.org/10.1200/jco.2023.41.16_suppl.102
PD-L1 quantification across tumor types using the reverse phase protein microarray: implications for precision medicine
https://doi.org/10.1136/jitc-2020-002179
Oral paclitaxel and dostarlimab with or without trastuzumab in early-stage, high-risk breast cancer: Results from the neoadjuvant ISPY 2 TRIAL.
https://doi.org/10.1200/jco.2023.41.17_suppl.lba612
Pexidartinib and standard neoadjuvant therapy in the adaptively randomized I-SPY2 trial for early breast cancer
https://doi.org/10.1007/s10549-024-07555-9
Pathological complete response to predict long term outcomes in the I-SPY2 TRIAL.
https://doi.org/10.1200/jco.2024.42.16_suppl.597
Use of PROMIS to capture patient reported outcomes over time for patients on I-SPY2.
https://doi.org/10.1200/jco.2023.41.16_suppl.611
Neratinib shows efficacy in the treatment of HER2 amplified carcinosarcoma in vitro and in vivo
https://doi.org/10.1016/j.ygyno.2015.08.002
Targeting immune checkpoints in breast cancer: an update of early results
https://doi.org/10.1136/esmoopen-2017-000255
How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies
https://doi.org/10.1136/esmoopen-2018-000357
Study designs for clinical trials applied to personalised medicine: a scoping review
https://doi.org/10.1136/bmjopen-2021-052926
Rates of pathologic complete response (pCR) after datopotamab deruxtecan (Dato) plus durvalumab (Durva) in the neoadjuvant setting: Results from the I-SPY2.2 trial.
https://doi.org/10.1200/jco.2024.42.17_suppl.lba501
Current Challenges in Cancer Treatment
https://doi.org/10.1016/j.clinthera.2016.03.026
Neratinib shows efficacy in the treatment of HER2/neu amplified uterine serous carcinoma in vitro and in vivo
https://doi.org/10.1016/j.ygyno.2014.08.006
Lifting the innate immune barriers to antitumor immunity
https://doi.org/10.1136/jitc-2020-000695
Evaluation of symptom severity, tolerability, and physical function in the I-SPY2 trial.
https://doi.org/10.1200/op.2023.19.11_suppl.369
Therapeutic response and outcomes with uncommon breast cancer subtypes in the I-SPY trial 2010-2022.
https://doi.org/10.1200/jco.2024.42.23_suppl.1
Rates of pathologic complete response (pCR)after neoadjuvant datopotamab deruxtecan (Dato): Results from the I-SPY2.2 trial.
https://doi.org/10.1200/jco.2024.42.17_suppl.lba509
I-SPY2 Endocrine Optimization Pilot (EOP): Neoadjuvant amcenestrant +/- abemaciclib +/- letrozole in molecularly selected patients (pts) with HR+ HER2- stage 2/3 breast cancer (BC).
https://doi.org/10.1200/jco.2024.42.16_suppl.601
A review of phase II trial designs for initial marker validation
https://doi.org/10.1016/j.cct.2013.05.001
Incidence and time to onset of immunotherapy-related adrenal insufficiency in the I-SPY2 trial.
https://doi.org/10.1200/jco.2024.42.16_suppl.584
Funding for this research was provided by:
Give Breast Cancer the Boot
National Institutes of Health (P01CA210961)
Quantum Leap Healthcare Collaborative
Foundation for the National Institutes of Health
Safeway Foundation
William K. Bowes, Jr. Foundation
Breast Cancer Research Foundation
Article History
Received: 18 October 2024
Accepted: 6 November 2024
First Online: 3 December 2024
Declarations
:
: HS Rugo has received unrelated institutional research funding and consulting fees from Daiichi-Sankyo, Inc. C Yau receives salary and travel support from Quantum Leap Healthcare Collaborative. A Jo Chien is a member of advisory board for AstraZeneca and Genentech. C Isaacs has received publishing royalties from UpToDate and McGraw Hill. J Boughey has received publishing royalties from UpToDate and honoraria from EndoMag, PER, PeerView and OncLive. HS Han is an advisory board member for Pfizer. M Buxton maintains a leadership position at the Global Coalition for Adaptive Research. R Singhrao is a salaried employee of F. Hoffmann-La Roche. L van‘t Veer has an ownership interest and receives a salary from Agendia NV, makers of MammaPrint. D Berry DAB is an employee of, has received travel support from, is an advisor and owns stock in Berry Consultants LLC; he has received unrelated funding from Daiichi-Sankyo. L Esserman has received publishing royalties from UpToDate and Wolters Kluwer Health; she is a board member of and receives grant funding from Quantum Leap Healthcare Collaborative, the sponsor of the I-SPY2 trial; she is a member of the Blue Cross Blue Shield Medical Advisory Board.