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Article History

Received: 9 March 2022

Accepted: 22 July 2022

First Online: 11 August 2022

Declarations

:

: Conflicts of interest/Competing interests: This work represents ongoing R&D between our group at Johns Hopkins Hospital and Canon Medical Systems. This study was supported by Canon Medical Systems Corporation, grant # 16–00632. Dr. Lima is the recipient of the grant. Drs Kassai and Liu are Canon Medical Systems employees in research and development roles, are members of the joint research group. We have been particularly careful at eliminating any perception of bias. Other co-authors have no conflict of interest. The authors have full control of all primary data and agree to allow the journal to review the data if requested.

: This work represents ongoing R&D between our group at Johns Hopkins Hospital and Canon Medical Systems. This study was supported by Canon Medical Systems Corporation, grant # 16–00632. Dr. Lima is the recipient of the grant. Drs Kassai and Liu are Canon Medical Systems employees in research and development roles, are members of the joint research group. We have been particularly careful at eliminating any perception of bias. Other co-authors have no conflict of interest. The authors have full control of all primary data and agree to allow the journal to review the data if requested.

: The study complied with the World Medical Association's Declaration of Helsinki. This study is registered with ClinicalTrials.gov, number NCT03768999. The Johns Hopkins School of Medicine institutional review board (IRB) approved the study protocol on Feb 17, 2020 with application number IRB00196000.

: Informed consent to participate was obtained from all individual participants included in the study.

: Informed consent for publication was obtained from all individual participants included in the study.