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Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium

Crossref DOI link: https://doi.org/10.1007/s10565-019-09508-1

Published Online: 2019-12-28

Published Print: 2020-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Song, Chenjian

Liu, Lingjing

Chen, Junjie

Hu, Yiran

Li, Jingli

Wang, Beibei

Bellusci, Saverio

Chen, Chengshui

Dong, Nian
Funding

Funding for this research was provided by:

Wenzhou Techinology Foundation (Y20180125)

The National Nature Science Foundation of China (81570075, 81770074)

Deutsche Forschungsgemeinschaft (DFG; BE4443/1-1, BE4443/4-1, BE4443/6-1, KFO309 P7 and SFB1213-projects A02 and A04)

Zhejiang Provincial Natural Science Foundation (LZ15H010001)

Zhejiang Provincial Science Technology Department Foundation (2015103253)

Zhejiang Provincial Science Technology Department Foundation (2020361718)

The National Key Research and Development Program of China (2016YFC1304000)
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Article History

Received: 13 May 2019

Accepted: 16 December 2019

First Online: 28 December 2019

Compliance with ethical standards

: All protocols for animal experiments were approved by the Animal Experiment Center Ethics Committee, The First Affiliated Hospital of Wenzhou Medical University.

: The authors declare that they have no competing interests.

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