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Single-cell transcriptome profiling reveals the heterogeneity of ossification of the posterior longitudinal ligament (OPLL) and its immune microenvironment

Crossref DOI link: https://doi.org/10.1007/s10565-026-10193-0

Published Online: 2026-04-18

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

He, Zhongyuan

Zhou, Jiaxiang

Wang, Fuan

Guo, Peng

Li, Jianfeng

Zhu, Zhengya

Tang, Tao

Tung, Nguyen Tran Canh

Kawaguchi, Yoshiharu

Liu, Shaoyu

Gao, ManMan

Liu, Xizhe

Zhou, Zhiyu
Funding

Funding for this research was provided by:

Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission

National Natural Science Foundation of China
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Text and Data Mining valid from 2026-04-18

Version of Record valid from 2026-05-29
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Article History

Received: 25 December 2025

Accepted: 11 April 2026

First Online: 18 April 2026

Declarations

:

: Ethical approval for the collection and use of human tissue specimens (No. 2020SYSUSH-055) was granted by the Ethics Committee of the Seventh Affiliated Hospital, Sun Yat-sen University. All animal procedures complied with the International Guide for the Care and Use of Laboratory Animals and were authorized by the Research Ethics Committee of the Sun Yat-Sen University (No. 2020000147).

: Written informed consent was obtained from the patient.

: Not applicable.

: The authors declare no competing interests.

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