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Article History

Received: 8 April 2025

Accepted: 10 June 2025

First Online: 24 July 2025

Declarations

:

: Dr. Bozorgmehr received research grants from BMS, Roche and AstraZeneca and personal fees (honoraria, advisory boards, travel support) from AstraZeneca, AMGEN, Novartis, Janssen, Novocure, GSK and Daiichi Sankyo. Dr. Atmaca received personal fees (travel support, advisory boards) from BMS, MSD, Roche, Takeda, Pfizer, Novartis, Astra Zeneca, Sanofi, Amgen, and Biontech. Dr. Faehling received personal fees (advisory boards) from BMS, AstraZeneca, and MSD. Dr. Wermke received research grant from Roche and personal fees (honoraria, consulting fees, travel support) from Lilly, Boehringer Ingelheim, SYNLAB, Janssen, Merck Serono, GWT, Amgen, Novartis, BMS, ISA Pharmaceuticals, immatics, Bayer, ImCheck therapeutics, Pfizer, AstraZeneca, GEMoaB, and Sanofi/Aventis. Dr. Troost received support from IBA. Dr. Kropf-Sanchen received personal fees (consulting fees, honoraria, travel support, advisory boards) from Astra Zeneca, Amgen, Art tempi/medtoday, BMS, Boehringer Ingelheim, Daichi, Lilly, Novartis, onkowissen, MSD, Pfizer, Roche, Sanofi, StreamedUp, and Takeda. Dr. Schuman received institutional and personal fees (honoraria, advisory boards) from AstraZeneca, BMS, Boehringer Ingelheim, Pfizer, and Roche. Dr. Reck received personal fees (consulting fees, honoraria, travel support, advisory board) from Amgen, AstraZeneca, Beigene, Boehringer Ingelheim, BMS, Daiichi-Sankyo, GSK, Mirati, Merck, MSD, Lilly, Novartis, Pfizer, Sanofi, Roche, and Regeneron. Dr. Würschmidt received personal fees (honoraria, travel support) from AstraZeneca and Siemens Varian. Dr. Stenzinger received research grants from Bayer, BMS, Chugai, and Incyte and honoraria from Aignostics, Amgen, Astellas, Astra Zeneca, Bayer, BMS, Eli Lilly, Illumina, Incyte, Janssen, MSD, Novartis, Pfizer, Qlucore, QuiP, Roche, Seagen, Servier, Takeda, and Thermo Fisher. Dr. Götze received grants from German Research Foundation (DFG), Gemeinsamer Bundesausschuss, German Cancer Aid, Lilly-Pharma, AstraZeneca, and Incyte and personal fees (consulting fees, honoraria, advisory board) from Amgen, AstraZeneca, Bayer, BMS, Daiichi Sankyo, FoundationMedicine, Lilly, MCI, MSD Sharp & Dohme, Novartis, Roche, Sanofi Aventis, Servier, Deciphera, and Boehringer Ingelheim. Dr. Christopoulos received research grants from Roche, Amgen, Boehringer Ingelheim, Takeda, Amgen, Merck, AstraZeneca, and Novartis and personal fees (honoraria, travel support, advisory board) from AstraZeneca, Gilead, Janssen, Novartis, Roche, Pfizer, Thermo Fisher, Takeda, Eli Lilly, Daiichi Sankyo, Boehringer Ingelheim, Chugai, Pfizer, and MSD. Dr. Debus received research grants from RaySearch Laboratories AB, Vision RT Limited, Merck Serono GmbH, Siemens Healthcare GmbH, PTW-Freiburg Dr. Pychlau GmbH, and Accuray Incorporated. Dr. Thomas received research grants from AstraZeneca, BMS, Merck, Roche, and Takeda and personal fees (honoraria, travel support) from Amgen, AstraZeneca, Beigene, BMS, Boehringer Ingelheim, Celgene, Chugai, Daiichi Sankyo, GSK, Janssen Oncology, Lilly, Merck, MSD, Novartis, Pfizer, Roche, Sanofi, and Takeda. The remaining authors declare no conflicts of interest.

: The trial was conducted in accordance with Good Clinical Practice and the Declaration of Helsinki. The study protocol was approved by the Ethics Committee of the Medical Faculty of the Heidelberg University. All patients provided written informed consent.

: Not applicable.